Heritability and recursive influence of host genetics on the rumen microbiota drive body weight variance in male Hu sheep lambs

Microbiome

Research

Jianghui Wang¹  Changchun Lin¹  Chong Li¹  Xiaoxue Zhang¹  Zhihua Jiang²  Ghasem Hosseini Salekdeh³  Xuezhi Ding⁴  Lvfeng Yuan⁵  Xiaolong Li⁶  Dan Xu⁶  Wanhong Li⁶  Liming Zhao⁶  Jiangbo Cheng⁶  Fadi Li⁶  Xiuxiu Wen⁶  Yukun Zhang⁶  Yuan Zhao⁶  Deyin Zhang⁶  Weimin Wang⁶  Xiangpeng Yue⁶ 

[1] College of Animal Science and Technology, Gansu Agricultural University, 730070, Lanzhou, China;Department of Animal Sciences and Center for Reproductive Biology, Washington State University (WSU), 99164, Pullman, WA, USA;Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia;Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), 730050, Lanzhou, China;Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), 730046, Lanzhou, China;State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology, Lanzhou University, 730020, Lanzhou, People’s Republic of China;

关键词: Sheep;    Host genetics;    Rumen microbiota;    Body weight;    Heritability;    Microbiota GWAS;    Microbiability;   

DOI  :  10.1186/s40168-023-01642-7

 received in 2023-01-13, accepted in 2023-08-07,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHeritable rumen microbiota is an important modulator of ruminant growth performance. However, no information exists to date on host genetics-rumen microbiota interactions and their association with phenotype in sheep. To solve this, we curated and analyzed whole-genome resequencing genotypes, 16S rumen-microbiota data, and longitudinal body weight (BW) phenotypes from 1150 sheep.ResultsA variance component model indicated significant heritability of rumen microbial community diversity. Genome-wide association studies (GWAS) using microbial features as traits identified 411 loci-taxon significant associations (P < 10−8). We found a heritability of 39% for 180-day-old BW, while also the rumen microbiota likely played a significant role, explaining that 20% of the phenotypic variation. Microbiota-wide association studies (MWAS) and GWAS identified four marker genera (Bonferroni corrected P < 0.05) and five novel genetic variants (P < 10−8) that were significantly associated with BW. Integrative analysis identified the mediating role of marker genera in genotype influencing phenotype and unravelled that the same genetic markers have direct and indirect effects on sheep weight.ConclusionsThis study reveals a reciprocal interplay among host genetic variations, the rumen microbiota and the body weight traits of sheep. The information obtained provide insights into the diverse microbiota characteristics of rumen and may help in designing precision microbiota management strategies for controlling and manipulating sheep rumen microbiota to increase productivity.FHBZi7VG9hPqSjx265vQ6eVideo Abstract

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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