The role of ubiquitination and deubiquitination in cancer metabolism

Molecular Cancer

Qing Yang¹  Tianshui Sun¹  Zhuonan Liu² 

[1] Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, 110004, Shenyang, China;Department of Urology, First Hospital of China Medical University, Shenyang, China;

关键词: Ubiquitination;    Deubiquitination;    Cancer;    Metabolic reprogramming;   

DOI  :  10.1186/s12943-020-01262-x

来源: Springer

【 摘 要 】

Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of cancer, sustaining cancer cell growth. Multiple signaling pathways, transcription factors and metabolic enzymes participate in the modulation of cancer metabolism and thus, metabolic reprogramming is a highly complex process. Recent studies have observed that ubiquitination and deubiquitination are involved in the regulation of metabolic reprogramming in cancer cells. As one of the most important type of post-translational modifications, ubiquitination is a multistep enzymatic process, involved in diverse cellular biological activities. Dysregulation of ubiquitination and deubiquitination contributes to various disease, including cancer. Here, we discuss the role of ubiquitination and deubiquitination in the regulation of cancer metabolism, which is aimed at highlighting the importance of this post-translational modification in metabolic reprogramming and supporting the development of new therapeutic approaches for cancer treatment.

【 授权许可】

CC BY