Multi-targeted Antisense Oligonucleotide Delivery by a Framework Nucleic Acid for Inhibiting Biofilm Formation and Virulence

Nano-Micro Letters

Xiaoru Shao¹  Yuxin Zhang¹  Xueping Xie¹  Chenchen Mao¹  Yuxi Zhan¹  Yunfeng Lin¹  Wenjuan Ma¹ 

[1] State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, People’s Republic of China;

关键词: Biofilm;    Framework nucleic acid;    Multi-targeting;    Antisense oligonucleotide;    Delivery system;   

DOI  :  10.1007/s40820-020-0409-3

来源: Springer

【 摘 要 】

tsA framework nucleic acid delivery system was developed through self-assembly, which can deliver antisense oligonucleotides against multiple targets in bacterial cells.The ASOs-tFNAs (750 nM) was found to simultaneously inhibit the expression of gtfBCD, gbpB, and ftf, and significantly reduce the extracellular polysaccharide synthesis and biofilm thickness.

【 授权许可】

CC BY