Application of intraoral scanner to identify monozygotic twins

BMC Oral Health

János Vág¹  Botond Simon¹  Laura Lipták²  Klaudia Lipták²  Dóra Melicher³  Dávid László Tárnoki⁴  Ádám Domonkos Tárnoki⁴ 

[1] Department of Conservative Dentistry, Semmelweis University, Szentkirályi, utca 47, H-1088, Budapest, Hungary;Faculty of Dentistry, Semmelweis University, Budapest, Hungary;Hungarian Twin Registry, Budapest, Hungary;Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary;MTA-SE Immunproteogenomics Extracellular Vesicle Research Group, Budapest, Hungary;Medical Imaging Center, Semmelweis University, Budapest, Hungary;Hungarian Twin Registry, Budapest, Hungary;

关键词: Palatal rugae;    Intraoral scanner;    Monozygotic twin;    Forensic odontology;    Human identification;    Palate;   

DOI  :  10.1186/s12903-020-01261-w

来源: Springer

【 摘 要 】

BackgroundDNA base identification is a proper and high specificity method. However, identification could be challenged in a situation where there is no database or the DNA sequence is almost identical, as in the case of monozygotic (MZ) twins. The aim of this study was to introduce a novel forensic method for distinguishing between almost identical MZ twins by means of an intraoral scanner using the 3D digital pattern of the human palate.MethodsThe palatal area of 64 MZ twins and 33 same-sex dizygotic (DZ) twins (DZSS) and seven opposite-sex dizygotic twins (DZOS) were scanned three times with an intraoral scanner. From the scanned data, an STL file was created and exported into the GOM Inspect® inspection software. All scans within a twin pair were superimposed on each other. The average deviation between scans of the same subject (intra-subject deviation, ISD) and between scans of the two siblings within a twin pair (intra-twin deviation, ITD) was measured. One-sided tolerance interval covering 99% of the population with 99% confidence was calculated for the ISD (upper limit) and the ITD (lower limit).ResultsThe mean ISD of the palatal scan was 35.3 μm ± 0.78 μm. The calculated upper tolerance limit was 95 μm. The mean ITD of MZ twins (406 μm ± 15 μm) was significantly (p < 0.001) higher than the ISD, and it was significantly lower than the ITD of DZSS twins (594 μm ± 53 μm, p < 0.01) and the ITD of DZOS twins (853 μm ± 202 μm, p < 0.05).ConclusionThe reproducibility of palatal intraoral scans proved to be excellent. The morphology of the palate shows differences between members of MZ twins despite their almost identical DNA, indicating that this method could be useful in forensic odontology.

【 授权许可】

CC BY