Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia

SCHIZOPHRENIA RESEARCH

卷:146

Article

Bloom, Rachael J.¹  Kahler, Anna K.^1,2,3  Collins, Ann L.¹  Chen, Guanhua⁴  Cannon, Tyrone D.^5,6  Hultman, Christina²  Sullivan, Patrick F.^1,2,7 

[1] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

[2] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[3] Oslo Univ Hosp Ulleval, Dept Psychiat, Oslo, Norway

[4] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA

[5] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

[6] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[7] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA

关键词: Schizophrenia;    Bipolar disorder;    Monozygotic twin;    Discordant;    Genetics;    Copy number variation;    Structural variation;   

DOI  :  10.1016/j.schres.2013.02.021

来源: Elsevier

【 摘 要 】

Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant for psychiatric disorders. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

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