One Stone Four Birds: A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy

Nano-Micro Letters

Shiyi Li¹  Jiaxuan Xia¹  Hongwei Ren¹  Anni Wang¹  Yizhen Guo¹  Chen Chen¹  Chao Hong¹  Jianxin Wang²  Jianming Liang³  Dan Wang⁴  Ying Zhu⁵  Chunyi Lu⁶  Huaxing Zhan⁷ 

[1] Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education, 201203, Shanghai, People’s Republic of China;Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education, 201203, Shanghai, People’s Republic of China;Institute of Integrated Chinese and Western Medicine, Fudan University, 200040, Shanghai, People’s Republic of China;Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education, 201203, Shanghai, People’s Republic of China;Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, 510006, Guangzhou, People’s Republic of China;Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education, 201203, Shanghai, People’s Republic of China;Shanghai Ginposome Pharmatech Co., Ltd, 201600, Shanghai, People’s Republic of China;Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, 510006, Guangzhou, People’s Republic of China;School of Pharmacy, Shanghai Jiao Tong University, 200240, Shanghai, People’s Republic of China;Shanghai Ginposome Pharmatech Co., Ltd, 201600, Shanghai, People’s Republic of China;

关键词: Ginsenoside Rh2;    Liposomes;    Cholesterol;    Multifunction;    Tumor targeting;   

DOI  :  10.1007/s40820-020-00472-8

来源: Springer

【 摘 要 】

tsA ginsenoside Rh2-based multifunctional liposome system (Rh2-lipo) was innovatively developed.Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component, but also provides another innovative potential system with multiple functions for anti-cancer drug delivery.

【 授权许可】

CC BY