The role of microenvironment in tumor angiogenesis

Journal of Experimental & Clinical Cancer Research

Zhaojian Gong¹  Shanshan Zhang²  Fang Xiong²  Xiayu Li³  Hao Deng³  Ke Cao³  Yi He⁴  Qianjin Liao⁴  Zhaoyang Zeng⁵  Xiaoling Li⁵  Bo Xiang⁵  Ming Zhou⁵  Wei Xiong⁵  Guiyuan Li⁵  Xianjie Jiang⁵  Xiangying Deng⁶  Can Guo⁶  Jie Wang⁶ 

[1] Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Stomatology, Xiangya Hospital, Central South University, Changsha, China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, China;NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China;NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China;The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, China;The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, China;

关键词: Tumor angiogenesis;    Tumor microenvironment;    Angiogenic factor;    Inflammatory factor;    Hypoxia inhibitor;   

DOI  :  10.1186/s13046-020-01709-5

来源: Springer

【 摘 要 】

Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment—composed of tumor cells, surrounding cells, and secreted cytokines—provides a conducive environment for the growth and survival of tumors. Different components of the tumor microenvironment can regulate tumor development. In this review, we have discussed the regulatory role of the microenvironment in tumor angiogenesis. High expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic drugs. A combination of anti-angiogenic drugs and antitumor inflammatory drugs or hypoxia inhibitors might improve the therapeutic outcome.

【 授权许可】

CC BY