Unidentified dengue serotypes in DENV positive samples and detection of other pathogens responsible for an acute febrile illness outbreak 2016 in Cajamarca, Peru

BMC Research Notes

Luis J. del Valle¹  Jorge Bazán-Mayra²  Victor Zavaleta-Gavidia²  Yordi Tarazona-Castro³  Fernando Vasquez-Achaya⁴  Johanna Martins-Luna⁵  Wilmer Silva-Caso⁵  Hugo Carrillo-Ng⁵  Miguel Angel Aguilar-Luis⁵  Juana del Valle-Mendoza⁵  Ronald Aquino-Ortega⁵ 

[1] Barcelona Research Center for Multiscale Science and Engineering, Departament D’Enginyeria Química, EEBE, Universitat Politècnica de Catalunya (UPC), Barcelona, Spain;Laboratorio Regional de Cajamarca, Dirección Regional de Salud de Cajamarca (DIRESA), Cajamarca, Peru;Laboratorio de Biologia Molecular, Instituto de Investigación Nutricional, Lima, Peru;Escuela Profesional de Genética y Biotecnología. Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, Lima, Peru;School of Medicine, Research and Innovation Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos cuadra 2, Chorrillos, Lima, Peru;School of Medicine, Research and Innovation Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos cuadra 2, Chorrillos, Lima, Peru;Laboratorio de Biologia Molecular, Instituto de Investigación Nutricional, Lima, Peru;

关键词: Peru;    Arbovirus;    Dengue;    Chikungunya;    Zika;    PCR;   

DOI  :  10.1186/s13104-020-05318-5

来源: Springer

【 摘 要 】

ObjectiveTo describe the prevalence of dengue virus serotypes, as well as other viral and bacterial pathogens that cause acute febrile illness during an outbreak in Cajamarca in 2016.ResultsDengue virus (DENV) was the most frequent etiologic agent detected in 25.8% of samples (32/124), followed by Rickettsia spp. in 8.1% (10/124), Zika virus in 4.8% (6/124), Chikungunya virus 2.4% (3/124) and Bartonella bacilliformis 1.6% (2/124) cases. No positive cases were detected of Oropouche virus and Leptospira spp. DENV serotypes identification was only achieved in 23% of the total positive for DENV, two samples for DENV-2 and four samples for DENV-4.During the 2016 outbreak in Cajamarca—Peru, it was observed that in a large percentage of positive samples for DENV, the infecting serotype could not be determined by conventional detection assays. This represents a problem for the national surveillance system and for public health due to its epidemiological and clinical implications. Other viral and bacterial pathogens responsible for acute febrile syndrome were less frequently identified.

【 授权许可】

CC BY