期刊论文详细信息
BMC Cancer
Prognosis prediction model based on competing endogenous RNAs for recurrence of colon adenocarcinoma
Jian Dong Tai1  Tao Liu1  Li Peng Jin1  Fan Qi Meng1 
[1] Department of Colorectal & Anal Surgery, First Hospital Bethune of Jilin University, No. 71, Xinmin Street, Chaoyang District, 130000, Changchun, Jilin, China;
关键词: Colon adenocarcinoma;    Recurrence;    Prognosis prediction model;    ceRNAs;   
DOI  :  10.1186/s12885-020-07163-y
来源: Springer
PDF
【 摘 要 】

BackgroundColon adenocarcinoma (COAD) patients who develop recurrence have poor prognosis. Our study aimed to establish effective prognosis prediction model based on competing endogenous RNAs (ceRNAs) for recurrence of COAD.MethodsCOAD expression profilings downloaded from The Cancer Genome Atlas (TCGA) were used as training dataset, and expression profilings of GSE29623 retrieved from Gene Expression Omnibus (GEO) were set as validation dataset. Differentially expressed RNAs (DERs) between non-recurrent and recurrent specimens in training dataset were screened, and optimum prognostic signature DERs were revealed to establish prognostic score (PS) model. Kaplan-Meier survival analysis was conducted for PS model, and GEO dataset was used for validation. Prognosis prediction efficiencies were evaluated by area under curve (AUC) and C-index. Meanwhile, ceRNA regulatory network was constructed by using signature mRNAs, lncRNAs and miRNAs.ResultsWe identified 562 DERs including 42 lncRNAs, 36 miRNAs, and 484 mRNAs. PS prediction model, consisting of 17 optimum prognostic signature DERs, showed that high risk group had significantly poorer prognosis (5-year AUC = 0.951, C-index = 0.788), which also validated in GSE29623. Prognosis prediction model incorporating multi-RNAs with pathologic distant metastasis (M) and pathologic primary tumor (T) (5-year AUC = 0.969, C-index = 0.812) had better efficiency than clinical prognosis prediction model (5-year AUC = 0.712, C-index = 0.680). In the constructed ceRNA regulatory network, lncRNA NCBP2-AS1 could interact with hsa-miR-34c and hsa-miR-363, and lncRNA LINC00115 could interact with hsa-miR-363 and hsa-miR-4709. SIX4, GRAP, NKAIN4, MMAA, and ERVMER34–1 are regulated by hsa-miR-4709.ConclusionPrognosis prediction model incorporating multi-RNAs with pathologic M and pathologic T may have great value in COAD prognosis prediction.

【 授权许可】

CC BY   

【 预 览 】
附件列表
Files Size Format View
RO202104262916192ZK.pdf 4127KB PDF download
  文献评价指标  
  下载次数:5次 浏览次数:9次