期刊论文详细信息
BMC Medicine
Maternal lipid profile in early pregnancy is associated with foetal growth and the risk of a child born large-for-gestational age: a population-based prospective cohort study
Jeanine E. Roeters Van Lennep1  Monique T. Mulder1  Eric A. P. Steegers2  Sarah Schalekamp-Timmermans3  Laura Benschop3  Alet W. Kors3  Kelly R. Peterbroers3  Anna M. Smak Gregoor3  Maria C. Adank3 
[1] Department of General Medicine, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands;Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands;Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands;Generation R Study Group, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands;
关键词: Pregnancy;    Lipoproteins;    Foetal weight;    Infant;    Small-for-gestational age;    Foetal programming;   
DOI  :  10.1186/s12916-020-01730-7
来源: Springer
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【 摘 要 】

BackgroundLipids such as cholesterol and triglycerides play an important role in both maternal and foetal energy metabolism. Little is known about maternal lipid levels in pregnancy and their effect on foetal growth. The aim of this study was to assess maternal lipid levels, foetal growth and the risk of small-for-gestational age (SGA) and large-for-gestational age (LGA).MethodsWe included 5702 women from the Generation R Study, a prospective population-based cohort. Maternal lipid levels (total cholesterol, triglycerides and high-density lipoprotein cholesterol [HDL-c]) were measured in early pregnancy (median 13.4 weeks, 90% range [10.5 to 17.2]). Low-density lipoprotein cholesterol (LDL-c), remnant cholesterol and non-HDL-c were calculated. Foetal growth was measured repeatedly by ultrasound. Information on birth anthropometrics was retrieved from medical records. A birth weight below the 10th percentile was defined as SGA and above the 90th percentile as LGA.ResultsMaternal triglyceride and remnant cholesterol levels were associated with increased foetal head circumference and abdominal circumference growth rates. Triglycerides and remnant cholesterol were positively associated with the risk of LGA (odds ratio [OR] 1.11, 95% confidence interval [CI] [1.01 to 1.22] and OR 1.11, 95% CI [1.01 to 1.23], respectively). These associations were independent of maternal pre-pregnancy body mass index, but not maternal glucose levels. We observed no association between maternal lipids in early pregnancy and SGA.ConclusionsOur study suggests a novel association of early pregnancy triglyceride and remnant cholesterol levels with foetal growth, patterns of foetal growth and the risk of LGA. Future studies are warranted to explore clinical implication possibilities.

【 授权许可】

CC BY   

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