Mechanism of antidiabetic effects of Plicosepalus Acaciae flower in streptozotocin-induced type 2 diabetic rats, as complementary and alternative therapy

BMC Complementary Medicine and Therapies

Mohamed-I Kotb El-Sayed¹  Hassan M Al-Mahbashi²  Amina El-Shaibany³  Shaza Al-Massarani⁴  Ali El Gamal⁵ 

[1] Department of Biochemistry and molecular Biology, Faculty of Pharmacy, Helwan University, P.O. Box 11790, Ain Helwan, Helwan, Cairo, Egypt;Department of Biochemistry, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt;Department of Forensic Medicine and Clinical toxicology, Faculty of Medicine, Sana’a University, Sana’a, Yemen;Department of Pharmacognosy, Faculty of Pharmacy, Sana’a University, Sana’a, Yemen;Department of Pharmacognosy, Pharmacy College, King Saud University, Riyadh, Saudi Arabia;Department of Pharmacognosy, Pharmacy College, King Saud University, Riyadh, Saudi Arabia;Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt;

关键词: Diabetes;    Antioxidant;    Metformin;    Plicosepalus Acaciae;    Quercetin;    Streptozotocin;   

DOI  :  10.1186/s12906-020-03087-z

来源: Springer

【 摘 要 】

BackgroundDiabetes and its related complications remain to be a major clinical problem. We aim to investigate the antidiabetic mechanistic actions of Plicosepalus Acaciae (PA) flowers in streptozotocin (STZ)-induced diabetic rats.MethodsAfter diabetes induction, rats were divided randomly into five groups, including: 1) normal control group, 2) diabetic control group, 3) diabetic group treated with 150 mg/kg of ethanolic extract of PA flowers, 4) diabetic group treated with 300 mg/kg of ethanolic extract of PA flowers, and 5) diabetic group treated with 150 mg/kg of metformin. After 15 days of treatment; fasting blood glucose, glycated hemoglobin (HBA1c%), insulin, C-peptide, superoxide dismutase (SOD), catalase, reduced glutathione (GSH), malondialdehyde (MDA), triglyceride (TGs), total cholesterol (Tc), low density lipoprotein cholesterol (LDL-c), very LDL (VLDL), high DLc (HDL-c), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels were assessed. Histopathology of pancreas was also assessed.ResultsThe results showed that PA flower ethanolic extract significantly reduced blood glucose, HBA1c%, MDA, TGs, Tc, VLDL, LDL-c, TNF-α, and IL-6 levels in a dose-dependent manner. All these parameters were already increased by diabetic induction in the untreated diabetic group. Treatment of diabetic rats with PA flower increased insulin, HDL-c, GSH, catalase, and SOD levels. Histological examination showed that the PA flower caused reconstruction, repair, and recovery of damaged pancreas when compared with the untreated group.ConclusionsPA flower has a potential role in the management of diabetes as complementary and alternative therapy, due to its antioxidant, anti-inflammatory, hypolipidemic, hypoglycemic and insulin secretagogue effects.

【 授权许可】

CC BY