Characteristics and trends of childhood cancer in Pudong, China, 2002–2015

BMC Public Health

Junqi Ji¹  Shilu Tong²  Shijian Liu³  Xiaopan Li⁴  Yichen Chen⁴  Xiaoyun Xu⁵  Zheng Luo⁵ 

[1] Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy Institute, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, 200127, Shanghai, China;Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy Institute, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, 200127, Shanghai, China;School of Public Health, Institute of Environment and Population Health, Anhui Medical University, Hefei, China;Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China;School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia;Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy Institute, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, 200127, Shanghai, China;School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Pudong New Area Center for Disease Control and Prevention, Fudan University Pudong Institute of Preventive Medicine, Pudong New Area, Shanghai, China;Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China;

关键词: Childhood cancer;    Incidence rate;    Survival rate;    Population-based cancer registry;    Time trends;   

DOI  :  10.1186/s12889-020-09493-9

来源: Springer

【 摘 要 】

BackgroundWith the growing threat of cancer to children’s health, it is necessary to analyze characteristics and trends of childhood cancer to formulate better cancer prevention strategies.MethodsData on the 430 children with cancer during 2002–2015 were collected from the Pudong Cancer Registry, diagnosed with the International Classification of Diseases for Oncology and categorized according to the International Classification of Childhood Cancer. The incidence rate, trends over time, and survival of patients grouped by sex, age, and region were explored using the Kaplan-Meier, Cox regression, and Joinpoint Regression models.ResultsThe crude childhood cancer incidence and world age-standardized incidence rate (ASR) were 115.1/1,000,000 and 116.3/1,000,000 person-years. The two most frequent cancers were leukemia (136/430, 31.63%, ASR, 37.8/1,000,000 person-years) and central nervous system (CNS) tumors (86/430, 20.00%, ASR, 22.9/1,000,000 person-years). Our findings indicate that the survival rate for children between 10 and 15 years of age was higher than that for 5–10; and the survival rate for children who had leukemia was higher than that of children with CNS tumors. However, the overall incidence of childhood cancer, and leukemia, CNS tumors remained relatively stable in Pudong between 2002 and 2015.ConclusionsThe incidence and survival rate for childhood cancer patients varied by age and cancer type. The overall trends of childhood cancer incidence remained relatively stable in Pudong from 2002 to 2015 even though socioeconomic development has been unprecedentedly fast in this region.

【 授权许可】

CC BY