Two seriously ill neonates born to mothers with COVID-19 pneumonia- a case report

Italian Journal of Pediatrics

Reza Atef-Yekta¹  Kourosh Sadeghi²  Ameneh Lamsehchi³  Setareh Sagheb³  Mohamadreza Jafary⁴ 

[1] Department of Anesthesiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;Department of Neonatology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;

关键词: Neonate;    Vertical transmission;    COVID-19;    SARS-COV-2;    Case report;   

DOI  :  10.1186/s13052-020-00897-2

来源: Springer

【 摘 要 】

BackgroundCoronavirus disease 2019 (COVID-19), a highly contagious viral disease has spread from Wuhan, Hubei Province, China to all over the world from its first recognition on December 2019. To date, only a few neonatal early-onset sepsis by SARS-COV-2 has been reported worldwide.Case presentationIn this report, we present two seriously ill neonates who were born from mothers with stablished COVID-19 pneumonia. Laboratory tests showed lymphopenia with high LDH and hypocalcemia right after the birth. They had fever for days without responding to antibiotics and despite ruling out other potential causes. Both patients had positive RTPCR for SARS-COV-2 in the second round of testing but the first assay tested was negative. Hydroxychloroquine was used to treat both patients; the first patient was treated with it over a period of 14 days before showing signs of improvement. The second patient responded to the treatment over a period of 5 days.ConclusionAlthough based on the available evidences, vertical transmission of COVID-19 is less likely, many aspects of pathogenesis and transmission of this novel virus are still unclear. Therefore we cannot rule out the vertical transmission totally. Further investigations are warranted to determine the exact mechanisms and routes of transmission.

【 授权许可】

CC BY