Calcitonin gene related peptide monoclonal antibody treats headache in patients with active idiopathic intracranial hypertension

The Journal of Headache and Pain

Susan P. Mollan¹  Edward Bilton¹  Julie Edwards²  Claire Fisher²  Gareth G. Lavery³  James L. Mitchell³  Vivek Vijay³  Alexandra J. Sinclair³  Olivia Grech³  Andreas Yiangou³ 

[1] Birmingham Neuro-Ophthalmology, Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, B15 2TH, Birmingham, UK;Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, B15 2TH, Birmingham, UK;Metabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK;Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, B15 2TH, Birmingham, UK;Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, B15 2TH, Birmingham, UK;

关键词: CGRP monoclonal antibody;    Headache;    Idiopathic intracranial hypertension;    Papilloedema;    Raised intracranial pressure;   

DOI  :  10.1186/s10194-020-01182-7

来源: Springer

【 摘 要 】

BackgroundHeadache is the dominant factor for quality of life related disability in idiopathic intracranial hypertension (IIH) and typically has migraine-like characteristics. There are currently no evidence-based therapeutics for headache in IIH, and consequently this is an important unmet clinical need.Case seriesWe report a series of seven patients in whom headaches were the presenting feature of IIH and the headaches had migraine-like characteristics, as is typical in many IIH patients. Papilloedema settled (ocular remission) but headaches continued. These headaches responded markedly to erenumab, a monoclonal antibody targeted against the calcitonin gene related peptide (CGRP) receptor. Of note, there was a recurrence of raised ICP, as evidenced by a return of the papilloedema, however the headaches did not recur whilst treated with erenumab.ConclusionsThose with prior IIH who have their headaches successfully treated with CGRP therapy, should remain under close ocular surveillance (particularly when weight gain is evident) as papilloedema can re-occur in the absence of headache. These cases may suggest that CGRP could be a mechanistic driver for headache in patients with active IIH.

【 授权许可】

CC BY