期刊论文详细信息
Archives of Clinical Psychiatry (São Paulo)
Association study in Alzheimer’s disease of single nucleotide polymorphisms implicated with coffee consumption
Victor Junji Yamamoto1  Vanessa De Jesus Rodrigues De Paula1  Orestes Vicente Forlenza1  Bernardo Dos Santos1  Daniel Shikanai Kerr1 
关键词: Caffeine;    Alzheimer’s disease;    SNP;   
DOI  :  10.1590/0101-60830000000050
来源: SciELO
PDF
【 摘 要 】
Background There is evidence from animal and in vitro models of the protective effects of caffeine in Alzheimer’s disease. The suggested mechanisms through which caffeine may protect neurons against Alzheimer’s disease pathology include the facilitation of beta-amyloid clearance, upregulation of cholinergic transmission, and increased neuronal plasticity and survival. Epidemiological studies support that Alzheimer’s disease patients consume smaller amounts of coffee beverages throughout their lives as compared to age-matched cognitively healthy individuals. Objective The aim of the present study was to determine whether the negative association between Alzheimer’s disease and coffee consumption may be influenced by a common genetic predisposition, given the fact that the pattern of coffee consumption is determined by both environmental and genetic factors. Method We conducted an in silico search addressing the association between genetic polymorphisms related to coffee consumption and the diagnosis of Alzheimer’s disease. We further investigated the interactions between genes located in regions bearing these polymorphisms. Results Our analysis revealed no evidence for a genetic association (nor interaction between related proteins) involving coffee consumption and Alzheimer’s disease. Discussion The negative association between Alzheimer’s disease and coffee consumption suggested by epidemiological studies is most likely due to environmental factors that are not necessarily regulated by genetic background.
【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

【 预 览 】
附件列表
Files Size Format View
RO202103040083441ZK.pdf 153KB PDF download
  文献评价指标  
  下载次数:次 浏览次数:次