Evaluation of 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice

Brazilian Journal of Medical and Biological Research

F.n. Carlesso¹  L.l. Fuscaldi¹  R.s. Araújo¹  C.s. Teixeira¹  M.c. Oliveira¹  S.o.a. Fernandes¹  G.d. Cassali¹  D.c. Reis¹  A.l.b. Barros¹  V.n. Cardoso¹ 

关键词: 99mTc-HYNIC-βAla-Bombesin;    Capan-1;    Scintigraphic images;    Pancreas tumor;    Biodistribution;   

DOI  :  10.1590/1414-431X20154506

来源: SciELO

【 摘 要 】

Pancreatic adenocarcinoma is important in oncology because of its high mortality rate. Deaths may be avoided if an early diagnosis could be achieved. Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic cancer cells. Thus, a radiolabeled peptide derivative of gastrin-releasing peptide (GRP) may be useful as a specific imaging probe. The purpose of the present study was to evaluate the feasibility of using99mTc-HYNIC-βAla-Bombesin(7-14)as an imaging probe for Capan-1 pancreatic adenocarcinoma. Xenographic pancreatic tumor was developed in nude mice and characterized by histopathological analysis. Biodistribution studies and scintigraphic images were carried out in tumor-bearing nude mice. The two methods showed higher uptake by pancreatic tumor when compared to muscle (used as control), and the tumor-to-muscle ratio indicated that99mTc-HYNIC-βAla-Bombesin(7-14)uptake was four-fold higher in tumor cells than in other tissues. Scintigraphic images also showed a clear signal at the tumor site. The present data indicate that99mTc-HYNIC-βAla-Bombesin(7-14)may be useful for the detection of pancreatic adenocarcinoma.

【 授权许可】

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