Functional and morphological effects of resistance exercise on disuse-induced skeletal muscle atrophy

Brazilian Journal of Medical and Biological Research

H. Nicastro²  N.e. Zanchi¹  C.r. Da Luz²  A.h. Lancha Jr.² 

[1] ,Universidade de São Paulo Escola de Educação Física e Esporte Laboratório de Nutrição e Metabolismo Aplicados a Atividade MotoraSão Paulo SP ,Brasil

关键词: Resistance exercise;    Vascular occlusion;    Eccentric exercise;    Disuse;    Atrophy;   

DOI  :  10.1590/S0100-879X2011007500125

来源: SciELO

【 摘 要 】

Abstract The reduction of skeletal muscle loss in pathological states, such as muscle disuse, has considerable effects in terms of rehabilitation and quality of life. Since there is no currently effective and safe treatment available for skeletal muscle atrophy, the search for new alternatives is necessary. Resistance exercise (RE) seems to be an important tool in the treatment of disuse-induced skeletal muscle atrophy by promoting positive functional (strength and power) and structural (hypertrophy and phenotypic changes) adaptive responses. Human and animal studies using different types of resistance exercise (flywheel, vascular occlusion, dynamic, isometric, and eccentric) have obtained results of great importance. However, since RE is a complex phenomenon, lack of strict control of its variables (volume, frequency, intensity, muscle action, rest intervals) limits the interpretation of the impact of the manipulation on skeletal muscle remodeling and function under disuse. The aim of this review is to critically describe the functional and morphological role of resistance exercise in disuse-induced skeletal muscle atrophy with emphasis on the principles of training.

【 授权许可】

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