Regulation and function of neurogenesis in the adult vertebrate brain

Brazilian Journal of Medical and Biological Research

R. Mendez-otero¹  C. Zaverucha-do-valle¹  F. Gubert¹  G.r. De Freitas¹  M.f. Santiago¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas Filho e Instituto do Milênio de Bioengenharia Tecidual Rio de Janeiro RJ ,Brasil

关键词: Neural stem cells;    Adult neurogenesis;    9-O-acetyl GD3;    Gangliosides;   

DOI  :  10.1590/S0100-879X2005001000012

来源: SciELO

【 摘 要 】

Most adult tissues retain a reservoir of self-renewing, multipotent stem cells that can generate differentiated tissue components. Until recently, the brain was thought to be an exception to this rule and for many years the pervasive dogma of neurobiology relegated neurogenesis to the embryonic and earlier postnatal stages of development. The discovery of constant neuronal replacement in the adult brain has changed the way we think about neurological diseases and about the exploration of new strategies for brain repair. In this review we will explore the potential of adult neural stem cells and we will present some of our own work on this subject. We will also discuss the possibility that adult neurogenesis and neuronal replacement may also play a role in therapies aimed at restoring impaired brain function. A better understanding of the various aspects of spontaneous neuronal replacement may also be used to increase the success of procedures with cell therapies.

【 授权许可】

CC BY   
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