Duration-controlled swimming exercise training induces cardiac hypertrophy in mice

Brazilian Journal of Medical and Biological Research

F.s. Evangelista²  P.c. Brum¹  J.e. Krieger² 

[1] ,Universidade de São Paulo Faculdade de Medicina Instituto do Coração

关键词: Exercise training;    Swimming;    Cardiac hypertrophy;    Mice;    Myocardium;   

DOI  :  10.1590/S0100-879X2003001200018

来源: SciELO

【 摘 要 】

Exercise training associated with robust conditioning can be useful for the study of molecular mechanisms underlying exercise-induced cardiac hypertrophy. A swimming apparatus is described to control training regimens in terms of duration, load, and frequency of exercise. Mice were submitted to 60- vs 90-min session/day, once vs twice a day, with 2 or 4% of the weight of the mouse or no workload attached to the tail, for 4 vs 6 weeks of exercise training. Blood pressure was unchanged in all groups while resting heart rate decreased in the trained groups (8-18%). Skeletal muscle citrate synthase activity, measured spectrophotometrically, increased (45-58%) only as a result of duration and frequency-controlled exercise training, indicating that endurance conditioning was obtained. In groups which received duration and endurance conditioning, cardiac weight (14-25%) and myocyte dimension (13-20%) increased. The best conditioning protocol to promote physiological hypertrophy, our primary goal in the present study, was 90 min, twice a day, 5 days a week for 4 weeks with no overload attached to the body. Thus, duration- and frequency-controlled exercise training in mice induces a significant conditioning response qualitatively similar to that observed in humans.

【 授权许可】

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