Biflavonoids inhibit the production of aflatoxin by Aspergillus flavus

Brazilian Journal of Medical and Biological Research

E. Gonçalez¹  J.d. Felicio¹  M.m. Pinto¹ 

[1] ,Instituto Biológico Centro de Sanidade Animal Laboratório de Produtos NaturaisSão Paulo SP ,Brasil

关键词: Ouratea sp;    Aspergillus flavus;    biflavonoids;    aflatoxins;   

DOI  :  10.1590/S0100-879X2001001100013

来源: SciELO

【 摘 要 】

The biflavonoids 6,6"-bigenkwanin, amenthoflavone, 7,7"-dimethoxyagastisflavone and tetradimethoxybigenkwanin isolated from Ouratea species were tested for inhibitory activity on Aspergillus flavus cultures. Suspensions of Aspergillus flavus spores were inoculated into 50 ml of YES medium at different biflavonoid concentrations: 5 and 10 µg/ml for 6,6"-bigenkwanin, amenthoflavone and 7,7"-dimethoxyagastisflavone, and 5, 10, 15 and 20 µg/ml for tetradimethoxybigenkwanin. The four biflavonoids showed inhibitory activity on aflatoxin B1 and B2 production (P<0.001), but did not inhibit fungal growth at the concentration tested (P>0.05). These results show that biflavonoids can be used for the development of agents to control aflatoxin production.

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