Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

Brazilian Journal of Medical and Biological Research

N. Isbil-buyukcoskun²  G. Gulec²  K. Ozluk²  I.h. Ulus¹ 

[1] ,Uludag University Medical Faculty Departments of Physiology

关键词: choline;    captopril;    intracerebroventricular choline;    blood pressure;   

DOI  :  10.1590/S0100-879X2001000600018

来源: SciELO

【 摘 要 】

In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv) choline (50, 100 and 150 µg) on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin system blockade on blood pressure increase induced by choline (150 µg, icv), an angiotensin-converting enzyme inhibitor, captopril (25 and 50 µg, icv), was administered 3 min before choline. Twenty-five µg captopril did not block the pressor effect of choline, while 50 µg captopril blocked it significantly. Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icv choline in normotensive rats.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License