Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Química Nova

University of Bucharest, Bucharest, Romania¹  Aboul-Enein, Hassan Y.¹  Badea, Irinel Adriana¹  Moldovan, Zenovia¹  National Research Centre, Cairo, Egypt¹  Bunaciu, Andrei A.¹  CROMATEC_PLUS SRL, Bucharest, Romania¹ 

关键词: captopril;    diphenylcarbazide;    spectrophotometric determination.;   

DOI  :  10.1590/S0100-40422012000800029

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A spectrophotometric method for the indirect determination of captopril (CP) in pharmaceutical formulations is proposed. The proposed procedure is based on the oxidation of captopril by potassium dichromate and the determination excess oxidant on the basis of its reaction with diphenylcarbazide (DPC). Under the optimum conditions, a good linear relationship (r = 0.9997) was obtained in the range of 0.08-3.5 µg mL-1. The assay limits of detection and quantitation were 0.024 and 0.08 µg mL-1, respectively. The results obtained for captopril determination in pharmaceuticals using the proposed method and those obtained with the US Pharmacopoeia method were in good agreement at the 95% confidence level.

【 授权许可】

Unknown