Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Química Nova

Zenovia Moldovan²  Irinel Adriana Badea²  Andrei A. Bunaciu¹  Hassan Y. Aboul-enein¹ 

[1] ,University of Bucharest Faculty of Chemistry Department of Analytical ChemistryBucharest,Romania

关键词: captopril;    diphenylcarbazide;    spectrophotometric determination;   

DOI  :  10.1590/S0100-40422012000800029

来源: SciELO

【 摘 要 】

A spectrophotometric method for the indirect determination of captopril (CP) in pharmaceutical formulations is proposed. The proposed procedure is based on the oxidation of captopril by potassium dichromate and the determination excess oxidant on the basis of its reaction with diphenylcarbazide (DPC). Under the optimum conditions, a good linear relationship (r = 0.9997) was obtained in the range of 0.08-3.5 µg mL-1. The assay limits of detection and quantitation were 0.024 and 0.08 µg mL-1, respectively. The results obtained for captopril determination in pharmaceuticals using the proposed method and those obtained with the US Pharmacopoeia method were in good agreement at the 95% confidence level.

【 授权许可】

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