Heparan sulfate and cell division

Brazilian Journal of Medical and Biological Research

M.a. Porcionatto¹  H.b. Nader¹  C.p. Dietrich¹ 

[1] ,Universidade Federal de São Paulo

关键词: heparan sulfate;    glycosaminoglycan;    proteoglycan;    cell division;    cell cycle;    growth factors;   

DOI  :  10.1590/S0100-879X1999000500006

来源: SciELO

【 摘 要 】

Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is modified during neoplastic transformation. Several lines of experimental evidence suggest that heparan sulfate plays a role in cellular recognition, cellular adhesion and growth control. Heparan sulfate can participate in the process of cell division in two distinct ways, either as a positive or negative modulator of cellular proliferation, or as a response to a mitogenic stimulus.

【 授权许可】

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