Effects of piperitenone oxide on the intestinal smooth muscle of the guinea pig

Brazilian Journal of Medical and Biological Research

P.j.c. Sousa¹  P.j.c. Magalhães¹  C.c. Lima¹  V.s. Oliveira¹  J.h. Leal-cardoso¹ 

关键词: piperitenone oxide;    Mentha x villosa;    ileum;    essential oil;    muscle relaxation;    acetylcholine;    K+-induced contraction;   

DOI  :  10.1590/S0100-879X1997000600014

来源: SciELO

【 摘 要 】

We investigated the effects of piperitenone oxide (PO), a major constituent of the essential oil of Mentha x villosa, on the guinea pig ileum. PO (30 to 740 µg/ml) relaxed basal tonus without significantly altering the resting membrane potential. In addition, PO relaxed preparations precontracted with either 60 mM K+ or 5 mM tetraethylammonium in a concentration-dependent manner. At concentrations from 0.1 to 10 µg/ml PO potentiated acetylcholine-induced contractions, while higher concentrations (>30 µg/ml) blocked this response. These higher PO concentrations also inhibited contractions induced by 60 mM K+. PO also blocked the components of acetylcholine contraction which are not sensitive to nifedipine or to solutions with nominal zero Ca2+ and EGTA. These results show that PO is a relaxant of intestinal smooth muscle and suggest that this activity may be mediated at least in part by an intracellular effect

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