Pesquisa Veterinária Brasileira | |
Selenium and vitamin E enriched diet increases NK cell cytotoxicity in cattle | |
Andréia O. Latorre2  Gisele F. Greghi1  Arlindo Saran Netto1  Heidge Fukumasu1  Júlio C. Balieiro1  Lisia B. Côrrea1  Marcus A. Zanetti1  | |
[1] ,Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Departamento de PatologiaSão Paulo SP ,Brasil | |
关键词: Selenium; vitamin E; NK cells; cytotoxicity; antioxidant; fatty acid; immunostimulation; Nellore bull; trace mineral; Selênio; vitamina E; citotoxicidade; células NK; antioxidantes; ácidos graxos; imunoestimulação; bovinos Nelore; micromineral; | |
DOI : 10.1590/S0100-736X2014001100018 | |
来源: SciELO | |
【 摘 要 】
A number of studies has shown that antioxidants, fatty acids and trace minerals may modulate different immune cell activities, and that their deficiency may be associated with diseases and impaired immune responses. In innate immunity, natural killer (NK) cells have a central role, killing virally infected and cancerous cells, and also secreting cytokines that shape adaptive immune responses. Thus, the aim of this study was to evaluate the effect of enriched diets in selenium plus vitamin E and/or canola oil on complete blood count and on NK cell cytotoxicity from blood lymphocytes of Nellore bulls. Bulls that received selenium plus vitamin E had (P=0.0091) higher NK cell cytotoxicity than control bulls. This result positively correlated with serum selenium levels. To the best of our knowledge, this is the first study that showed immunostimulatory effects of selenium plus vitamin E on NK cell cytotoxicity of Nellore bulls.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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