Selenium and vitamin E enriched diet increases NK cell cytotoxicity in cattle

Pesquisa Veterinária Brasileira

Andréia O. Latorre²  Gisele F. Greghi¹  Arlindo Saran Netto¹  Heidge Fukumasu¹  Júlio C. Balieiro¹  Lisia B. Côrrea¹  Marcus A. Zanetti¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Departamento de PatologiaSão Paulo SP ,Brasil

关键词: Selenium;    vitamin E;    NK cells;    cytotoxicity;    antioxidant;    fatty acid;    immunostimulation;    Nellore bull;    trace mineral;    Selênio;    vitamina E;    citotoxicidade;    células NK;    antioxidantes;    ácidos graxos;    imunoestimulação;    bovinos Nelore;    micromineral;   

DOI  :  10.1590/S0100-736X2014001100018

来源: SciELO

【 摘 要 】

A number of studies has shown that antioxidants, fatty acids and trace minerals may modulate different immune cell activities, and that their deficiency may be associated with diseases and impaired immune responses. In innate immunity, natural killer (NK) cells have a central role, killing virally infected and cancerous cells, and also secreting cytokines that shape adaptive immune responses. Thus, the aim of this study was to evaluate the effect of enriched diets in selenium plus vitamin E and/or canola oil on complete blood count and on NK cell cytotoxicity from blood lymphocytes of Nellore bulls. Bulls that received selenium plus vitamin E had (P=0.0091) higher NK cell cytotoxicity than control bulls. This result positively correlated with serum selenium levels. To the best of our knowledge, this is the first study that showed immunostimulatory effects of selenium plus vitamin E on NK cell cytotoxicity of Nellore bulls.

【 授权许可】

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