Impact of Roux-en-Y gastric bypass on lipid and inflammatory profiles

Revista do Colégio Brasileiro de Cirurgiões

Cleiton Da Silva Oliveira¹  Bruna Teles Soares Beserra¹  Raphael Salles Granato Cunha¹  Ana Gabriela Estevam Brito¹  Rafaella Cristina Dimbarre De Miranda¹  Lúcia Andréia Zanette Ramos Zeni¹  Everson Araújo Nunes¹  Erasmo Benicio Santos De Moraes Trindade¹ 

关键词: Gastric Bypass;    Obesity;    Inflammation Mediators;    Weight Loss;    Derivação Gástrica;    Obesidade;    Mediadores da Inflamação;    Perda de Peso;   

DOI  :  10.1590/0100-69912015005007

来源: SciELO

【 摘 要 】

Objective:To evaluate the behavior of acute phase proteins and lipid profile in patients undergoing Roux-en-Y gastric bypass.Methods : We conducted a prospective study, consisting of three moments: M1 - preoperative (24 hours before surgery); M2 - 30 days after surgery; and M3 - 180 days after surgery. We carried measured height and BMI, as well as determined the concentrations of acute phase proteins (C-reactive protein (CRP), albumin and Alpha-1-acid glycoprotein) and total cholesterol, LDL-c, HDL-c and triacylglycerol.Results : participants comprised 25 individuals, with a mean age of 39.28 ± 8.07, 72% female. At all times of the study there was statistically significant difference as for weight loss and BMI. We found a significant decrease in CRP concentrations between the moments M1 and M3 (p = 0.041) and between M2 and M3 (p = 0.018). There was decrease in Alpha-1-GA concentrations between M1 and M2 (p = 0.023) and between M1 and M3 (p = 0.028). The albumin values increased, but did not differ between times. Total cholesterol and triacylglycerol decreased significantly ay all times. LDL-c concentrations decreased and differed between M1 and M2 (p = 0.001) and between M1 and M3 (p = 0.001). HDL-c values increased, however only differing between M1 and M2 (p = 0.050).Conclusion : Roux-en-Y gastric bypass promoted a decrease in plasma concentrations of CRP and Alpha-1-acid glycoprotein, improving lipid and inflammatory profiles.

【 授权许可】

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