Estudo químico e atividades antiproliferativa, tripanocida e leishmanicida de Maxillaria picta

Química Nova

Thiago L. De Almeida²  Josiane A. Monteiro²  Greice K. P. Lopes²  Lucas U. R. Chiavelli²  Silvana M. De O. Santin²  Cleuza C. Da Silva²  Vanessa Kaplum¹  Débora B. Scariot¹  Celso V. Nakamura¹  Ana L. T. G. Ruiz¹  João E. Carvalho¹  Ricardo T. De Faria¹  Armando M. Pomini² 

[1] ,Universidade Estadual de Maringá Departamento de Química Maringá PR ,Brasil

关键词: Maxillaria;    Trypanosoma;    Leishmania;    stilbenes;   

DOI  :  10.5935/0100-4042.20140179

来源: SciELO

【 摘 要 】

The chemical study of the orchid Maxillaria picta resulted in the isolation of the bioactive stilbenes phoyunbene B and phoyunbene C, in addition to four phenolic acids, one xanthone, steroidal compounds and two triterpenes. Crude extract, fractions, subfractions and the isolated xanthone were evaluated for anticancer activity against human tumor cell lines and against evolutionary forms of T. cruzi and L. amazonensis. The structures of the compounds were determined by GC-MS, and ¹H NMR, 13C NMR spectral methods as well as bidimensional techniques.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License