Chemical study and antiproliferative, trypanocidal and leishmanicidal activities of Maxillaria picta

Quimica nova

Carvalho, João E.¹  Ruiz, Ana L. T. G.¹  Faria, Ricardo T. de²  Kaplum, Vanessa³  Silva, Cleuza C. da³  Nakamura, Celso V.³  Almeida, Thiago L. de³  Santin, Silvana M. de O.³  Pomini, Armando M.³  Scariot, Débora B.³  Chiavelli, Lucas U. R.³  Monteiro, Josiane A.³  Lopes, Greice K. P.³ 

[1] Universidade Estadual de Campinas, Paulínia, Brasil;Universidade Estadual de Londrina, Londrina, Brasil;Universidade Estadual de Maringá, Maringá, Brasil

关键词: Maxillaria;    Trypanosoma;    Leishmania;    stilbenes.;   

DOI  :  10.5935/0100-4042.20140179

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The chemical study of the orchid Maxillaria picta resulted in the isolation of the bioactive stilbenes phoyunbene B and phoyunbene C, in addition to four phenolic acids, one xanthone, steroidal compounds and two triterpenes. Crude extract, fractions, subfractions and the isolated xanthone were evaluated for anticancer activity against human tumor cell lines and against evolutionary forms of T. cruzi and L. amazonensis. The structures of the compounds were determined by GC-MS, and 1H NMR, 13C NMR spectral methods as well as bidimensional techniques.

【 授权许可】

CC BY