Synthesis and evaluation of octocrylene-inspired compounds for UV-filter activity

Química Nova

Hudson C. Polonini²  Rosângela S. Lopes¹  Adilson Beatriz¹  Roberto S. Gomes¹  Adriano O. Silva¹  Ricardo V. De Lima¹  Gláucia. A. Nunes¹  Marcos Antônio F. Brandão²  Nádia R. B. Raposo²  Dênis P. De Lima¹ 

[1] ,Universidade Federal de Juiz de Fora Núcleo de Pesquisa e Inovação em Ciências da Saúde Juiz de Fora MG ,Brasil

关键词: sunscreens;    octocrylene;    photoprotective activity;   

DOI  :  10.5935/0100-4042.20140160

来源: SciELO

【 摘 要 】

Octocrylene (2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate) is present in several sunscreens and is known to work synergistically with UV filters. We prepared eight octocrylene-related compounds to test their photoprotective activities by measuring diffuse transmittance. The compounds had varied photoprotection profiles, with Sun Protection Factors (SPF) ranging from 1 to 5 and UVA Protection Factors (UVAPF) ranging from 1 to 8. Compounds 4, 5, and 7 showed the best protection against UVB sunrays, while compounds 5, 6, and 7 presented the best results for protection from UVA, so compound 7 had the most balanced protection overall. Results for compounds 4, 8, and 9 are reported for the first time in the literature.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License