Synthesis and evaluation of octocrylene-inspired compounds for UV-filter activity

Química Nova

Beatriz, Adilson¹  Brandão, Marcos Antônio F.¹  Nunes, Gláucia. A.¹  Lopes, Rosângela S.¹  Polonini, Hudson C.¹  Lima, Ricardo V. de¹  Gomes, Roberto S.¹  Lima, Dênis P. de¹  Raposo, Nádia R. B.¹  Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil¹  Universidade Federal de Mato Grosso do Sul, Campo Grande, Brasil¹  Silva, Adriano O.¹ 

关键词: sunscreens;    octocrylene;    photoprotective activity.;   

DOI  :  10.5935/0100-4042.20140160

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Octocrylene (2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate) is present in several sunscreens and is known to work synergistically with UV filters. We prepared eight octocrylene-related compounds to test their photoprotective activities by measuring diffuse transmittance. The compounds had varied photoprotection profiles, with Sun Protection Factors (SPF) ranging from 1 to 5 and UVA Protection Factors (UVAPF) ranging from 1 to 8. Compounds 4, 5, and 7 showed the best protection against UVB sunrays, while compounds 5, 6, and 7 presented the best results for protection from UVA, so compound 7 had the most balanced protection overall. Results for compounds 4, 8, and 9 are reported for the first time in the literature.

【 授权许可】

Unknown