Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS

Química Nova

Vanessa De Jesus Gaffney²  Vitor Vale Cardoso¹  Alexandre Rodrigues¹  Elisabete Ferreira¹  Maria João Benoliel¹  Cristina M. M. Almeida² 

[1] ,Universidade de Lisboa Faculdade de Farmácia Institute for Medicines and Pharmaceutical SciencesLisboa,Portugal

关键词: water;    pharmaceutical compounds;    UPLC-MS/MS;   

DOI  :  10.1590/S0100-40422014000100023

来源: SciELO

【 摘 要 】

A method was developed for the analysis of 31 pharmaceutical compounds in Lisbon's drinking water system, using solid-phase extraction (SPE) and ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). The method was validated through estimation of the linearity range, method detection and quantification limits, matrix effects, precision and accuracy. The method detection and quantification limit ranges were 0.009-10 and 0.03-33 ng/L, respectively. Analytes were quantified in water samples collected from the EPAL (Empresa Portuguesa das Águas Livres S.A.) supply system. Carbamazepine, atenolol, sulfadiazine, sulfamethazine, sulfapyridine, sulfamethoxazole, acetaminophen, caffeine and erythromycin were quantified in the analysed samples.

【 授权许可】

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