Analysis of pharmaceutical compounds in water by SPE-UPLC-ESI-MS/MS

Química Nova

Empresa Portuguesa das Águas Livres, S.A., Lisboa, Portugal¹  Ferreira, Elisabete¹  Almeida, Cristina M. M.¹  Cardoso, Vitor Vale¹  Gaffney, Vanessa de Jesus¹  Benoliel, Maria João¹  Rodrigues, Alexandre¹  Universidade de Lisboa, Lisboa, Portugal¹ 

关键词: water;    pharmaceutical compounds;    UPLC-MS/MS.;   

DOI  :  10.1590/S0100-40422014000100023

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A method was developed for the analysis of 31 pharmaceutical compounds in Lisbon's drinking water system, using solid-phase extraction (SPE) and ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). The method was validated through estimation of the linearity range, method detection and quantification limits, matrix effects, precision and accuracy. The method detection and quantification limit ranges were 0.009-10 and 0.03-33 ng/L, respectively. Analytes were quantified in water samples collected from the EPAL (Empresa Portuguesa das Águas Livres S.A.) supply system. Carbamazepine, atenolol, sulfadiazine, sulfamethazine, sulfapyridine, sulfamethoxazole, acetaminophen, caffeine and erythromycin were quantified in the analysed samples.

【 授权许可】

Unknown