Atividade de extratos de Arrabidaea chica (Humb. & Bonpl.) Verlot obtidos por processos biotecnológicos sobre a proliferação de fibroblastos e células tumorais humanas

Química Nova

Denise Taffarello²  Michelle Pedroza Jorge¹  Ilza Maria De Oliveira Sousa¹  Marta Cristina Teixeira Duarte¹  Glyn Mara Figueira¹  Nubia De Cassia Almeida Queiroz¹  Rodney Alexandre Ferreira Rodrigues¹  João Ernesto De Carvalho¹  Ana Lucia Tasca Ruiz Goes¹  Mary Ann Foglio¹  José Manuel Riveros¹  Marcos Nogueira Eberlin¹  Elaine Cristina Cabral¹ 

[1] ,Universidade Estadual de Campinas Centro Pluridisciplinar de Pesquisa Química, Biológicas e Agrícolas Campinas SP ,Brasil

关键词: Arrabidaea chica;    xylanases;    antiproliferative activity;   

DOI  :  10.1590/S0100-40422013000300014

来源: SciELO

【 摘 要 】

Arrabidaea chica (H&B) Verlot is a plant popularly known as Pariri and this species is a known source of anthocyanins, flavonoids and tannins. This report describes an approach involving enzymatic treatment prior to extraction procedures to enhance A chica crude extract anticancer activity. Anticancer activity in human cancer cell lines in vitro using a 48 h SRB cell viability assay was performed to determine growth inhibition and cytotoxic properties. The final extraction yield without enzyme treatment was higher (24.28%) compared to the enzyme-treated material (19.03%), with an enhanced aglycones anthocyanin ratio as determined by HPLC- DAD and LC-MS with direct infusion.

【 授权许可】

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