Activity of Arrabidaea chica (Humb. & Bonpl.) Verlot extracts obtained by biotechnological processes on fibroblast and human tumor cells

Química Nova

Taffarello, Denise¹  Riveros, José Manuel¹  Universidade Estadual de Campinas, Brasil¹  Universidade Estadual de Campinas, Campinas, Brasil¹  Rodrigues, Rodney Alexandre Ferreira¹  Universidade de São Paulo, SP, Brasil¹  Cabral, Elaine Cristina¹  Foglio, Mary Ann¹  Figueira, Glyn Mara¹  Jorge, Michelle Pedroza¹  Duarte, Marta Cristina Teixeira¹  Carvalho, João Ernesto de¹  Eberlin, Marcos Nogueira¹  Goes, Ana Lucia Tasca Ruiz¹  Queiroz, Nubia de Cassia Almeida¹  Sousa, Ilza Maria de Oliveira¹ 

关键词: Arrabidaea chica;    xylanases;    antiproliferative activity.;   

DOI  :  10.1590/S0100-40422013000300014

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Arrabidaea chica (H&B) Verlot is a plant popularly known as Pariri and this species is a known source of anthocyanins, flavonoids and tannins. This report describes an approach involving enzymatic treatment prior to extraction procedures to enhance A chica crude extract anticancer activity. Anticancer activity in human cancer cell lines in vitro using a 48 h SRB cell viability assay was performed to determine growth inhibition and cytotoxic properties. The final extraction yield without enzyme treatment was higher (24.28%) compared to the enzyme-treated material (19.03%), with an enhanced aglycones anthocyanin ratio as determined by HPLC- DAD and LC-MS with direct infusion.

【 授权许可】

Unknown