Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms

Química Nova

Aline Ferreira Ourique²  Renata Vidor Contri²  Silvia Stanisçuaski Guterres²  Ruy Carlos Ruver Beck²  Adriana Raffin Pohlmann¹  Ana Melero¹  Ulrich F. Schaefer¹ 

[1] ,Universidade Federal do Rio Grande do Sul Faculdade de Farmácia Departamento de Produção e Controle de MedicamentosPorto Alegre RS ,Brasil

关键词: pharmaceuticals;    liquid chromatography;    mometasone;   

DOI  :  10.1590/S0100-40422012000400030

来源: SciELO

【 摘 要 】

A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 µg mL-1. The method provided acceptable theoretical plates, peak simmetry, peak tailing factor and peak resolution a short run (5 min). The method showed specificity, good linearity (r = 0.9999) and the quantification limit was 0.379 µg mL-1. Furthermore, the method was precise (RSD < 2.0%), accurate (recovery > 97%) and robust.

【 授权许可】

CC BY-NC   
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