Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorial

Química Nova

Eliana B Souto²  Patrícia Severino²  Maria Helena A Santana¹  Samantha C Pinho¹ 

[1] ,Universidade Fernando Pessoa Faculdade de Ciências da Saúde Porto

关键词: solid lipid nanoparticle;    production of methods;    technological parameters;   

DOI  :  10.1590/S0100-40422011001000009

来源: SciELO

【 摘 要 】

Solid lipid nanoparticles have been extensively investigated as drug delivery systems. These colloidal systems have major advantages compared to others more traditional. Reported advantages include sustained release, ability to solubilize lipophilic drugs, increased physical and chemical stability of labile molecules, decreased unwanted side-effects showing lower toxicity, and scale up facilities. This paper aims at reviewing the traditional methods of solid lipid nanoparticles production, such as fusion-emulsification (hot and cold), solvent evaporation-emulsification and microemulsion, dealing with the main technological parameters that influence the quality properties of solid lipid nanoparticles.

【 授权许可】

CC BY-NC   
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