Solid lipid nanoparticles: classical methods of lab production

Química Nova

Severino, Patrícia¹  Souto, Eliana B¹  Universidade de Campinas, Campinas, Brasil¹  Universidade Fernando Pessoa, Porto¹  Pinho, Samantha C¹  Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal¹  Universidade de São Paulo, Pirassununga, Brasil¹  Santana, Maria Helena A¹ 

关键词: solid lipid nanoparticle;    production of methods;    technological parameters.;   

DOI  :  10.1590/S0100-40422011001000009

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Solid lipid nanoparticles have been extensively investigated as drug delivery systems. These colloidal systems have major advantages compared to others more traditional. Reported advantages include sustained release, ability to solubilize lipophilic drugs, increased physical and chemical stability of labile molecules, decreased unwanted side-effects showing lower toxicity, and scale up facilities. This paper aims at reviewing the traditional methods of solid lipid nanoparticles production, such as fusion-emulsification (hot and cold), solvent evaporation-emulsification and microemulsion, dealing with the main technological parameters that influence the quality properties of solid lipid nanoparticles.

【 授权许可】

Unknown