Síntese, caracterização e estudo da atividade inibitória de novas dialquilfosforilarilidrazonas sobre o crescimento de tripanossomatídeos

Química Nova

Andréa Janaina M. Nogueira²  Marco Edilson F. De Lima²  João Batista N. Dacosta²  Eliomara Sousa Sobral Alves¹  Danielle Oliveira Dos Anjos¹  Marcos André Vannier-santos¹  Adriana Lanfredi-rangel¹ 

[1] ,Universidade Federal Rural do Rio de Janeiro Instituto de Ciências Exatas Departamento de QuímicaSeropédica RJ ,Brasil

关键词: leishmaniases;    Chagas disease;    dialkylphosphorylhydrazones;   

DOI  :  10.1590/S0100-40422011000800013

来源: SciELO

【 摘 要 】

A new series of dialkylphosphorylhydrazones was synthesized through the condensation of aromatic aldehydes with different phosphorylhydrazines. All synthesized compounds were characterized by IR, ¹H-NMR, 13C-NMR and 31P-NMR spectroscopies. The in vitro investigation of the activity of these compounds against Leishmania amazonensis promastigotes and epimastigotes of T. cruzi, showed an efficient inhibition of proliferation, at non toxic concentrations to mammalian cells. The results have shown some derivatives as potential antiparasitic agents against trypanosomatids.

【 授权许可】

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