Synthesis, caracterization and study of activity inhibitory of new dialkylphosphoryl-hydrazones on the growth of trypanosomatids

Química Nova

Fundação Oswaldo Cruz, Salvador, Brasil¹  Nogueira, Andréa Janaina M.¹  Universidade Federal Rural do Rio de Janeiro, Seropédica, Brasil¹  Alves, Eliomara Sousa Sobral¹  Lanfredi-Rangel, Adriana¹  Anjos, Danielle Oliveira dos¹  DaCosta, João Batista N.¹  Lima, Marco Edilson F. de¹  Vannier-Santos, Marcos André¹ 

关键词: leishmaniases;    Chagas disease;    dialkylphosphorylhydrazones.;   

DOI  :  10.1590/S0100-40422011000800013

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A new series of dialkylphosphorylhydrazones was synthesized through the condensation of aromatic aldehydes with different phosphorylhydrazines. All synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR and 31P-NMR spectroscopies. The in vitro investigation of the activity of these compounds against Leishmania amazonensis promastigotes and epimastigotes of T. cruzi, showed an efficient inhibition of proliferation, at non toxic concentrations to mammalian cells. The results have shown some derivatives as potential antiparasitic agents against trypanosomatids.

【 授权许可】

Unknown