Preparação e caracterização de suspensões coloidais de nanocarreadores lipídicos contendo resveratrol destinados à administração cutânea

Química Nova

Daiane Nemen¹  Elenara Lemos-senna¹ 

[1] ,Universidade Federal de Santa Catarina Departamento de Ciências Farmacêuticas Centro de Ciências da SaúdeFlorianopolis SC ,Brasil

关键词: resveratrol;    lipid-based nanocarriers;    hydrogels;   

DOI  :  10.1590/S0100-40422011000300008

来源: SciELO

【 摘 要 】

Solid lipid nanoparticles (SLN), nanoemulsions (NE), and microemulsions (ME) were prepared by the hot solvent diffusion method, using tristearin or castor oil as oily phase, and soy lecithin and Solutol HS 15 as surfactants. Mean particle sizes ranged from 20 to 215 nm and negative zeta potentials were obtained for all nanocarriers. A HPLC method used to determine resveratrol was specific, linear, exact and precise. The entrapment efficiency was high for all formulations. However, resveratrol content was significantly varied among the lipid nanocarriers. Lipid nanocarrier containing hydrogels exhibiting pseudoplastic behavior were obtained after incorporation of hydroxyethylcellulose in the colloidal dispersions.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License