Preparation and characterization of resveratrol-loaded lipid-based nanocarriers for cutaneous administration

Quimica nova

Nemen, Daiane¹  Lemos-Senna, Elenara¹ 

[1] Universidade Federal de Santa Catarina, Florianopolis, Brasil

关键词: resveratrol;    lipid-based nanocarriers;    hydrogels.;   

DOI  :  10.1590/S0100-40422011000300008

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Solid lipid nanoparticles(SLN), nanoemulsions (NE), and microemulsions (ME) were prepared by the hotsolvent diffusion method, using tristearin or castor oil as oily phase, andsoy lecithin and Solutol HS 15 as surfactants. Mean particle sizes ranged from20 to 215 nm and negative zeta potentials were obtained for all nanocarriers.A HPLC method used to determine resveratrol was specific, linear, exact andprecise. The entrapment efficiency was high for all formulations. However, resveratrolcontent was significantly varied among the lipid nanocarriers. Lipid nanocarriercontaining hydrogels exhibiting pseudoplastic behavior were obtained after incorporationof hydroxyethylcellulose in the colloidal dispersions.

【 授权许可】

CC BY