Química Nova | |
Glicoproteína-P, resistência a múltiplas drogas (MDR) e relação estrutura-atividade de moduladores | |
Paula C. Huber1  Cintia H. Maruiama1  Wanda P. Almeida1  | |
[1] ,Universidade Estadual de Campinas Instituto de Química Departamento de Química OrgânicaCampinas SP ,Brasil | |
关键词: P-glycoprotein; multidrug resistance; modulators; | |
DOI : 10.1590/S0100-40422010001000027 | |
来源: SciELO | |
【 摘 要 】
Multidrug resistance, MDR is a major obstacle for cancer chemotherapy. MDR can be reversed by drugs that vary in their chemical structure and main biological activity. Many efforts have been done to overcome MDR based on studies of structure-activity relationships and in this review we summarize some aspects of MDR mediated by P-glycoprotein (P-gp), as the most experimentally and clinically tested form of drug resistance. The most significant MDR mechanisms revealed until now are shortly discussed. Physicochemical and structural properties of MDR modulators, measures of the MDR reversal, and QSAR studies are included.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
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RO202103040063431ZK.pdf | 515KB | download |