Desenvolvimento de método analítico para quantificação do efavirenz por espectrofotometria no UV-Vis

Química Nova

Lariza Darlene Santos Alves²  Larissa Araújo Rolim²  Danilo Augusto Ferreira Fontes²  Pedro José Rolim-neto²  Mônica Felts De La Roca Soares¹  José Lamartine Soares Sobrinho¹ 

[1] ,Universidade Federal de Pernambuco Departamento de Ciências Farmacêuticas Recife PE ,Brasil

关键词: UV-Vis spectroscopy;    Efavirenz;    analytical method;   

DOI  :  10.1590/S0100-40422010000900026

来源: SciELO

【 摘 要 】

An UV-Vis spectrophotometry analytical method for quantifying Efavirenz was developed and validated as an alternative to replace the HPLC current method. The report method presents sample concentration of 10 μg mL-1, dissolved in a solution ethanol:water (60:40, v/v), economic and technically adequate for the purpose adopted. The results and the statistical treated proved that the method being considered an precise and accurate analytical low cost alternative for laboratory routine. The adaptability of this method in product and other analytical methods development has been challenged by mathematical calculation of drug extinction coefficient in water and methanol and practical experiments, showing interesting results.

【 授权许可】

CC BY-NC   
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