UV-Vis spectrophotometry analytical method development for quantifying efavirenz

Química Nova

Rolim, Larissa Araújo¹  Universidade Federal do Piauí, Teresina, Brasil¹  Rolim-Neto, Pedro José¹  Soares Sobrinho, José Lamartine¹  Alves, Lariza Darlene Santos¹  Soares, Mônica Felts de La Roca¹  Universidade Federal de Pernambuco, Recife, Brasil¹  Fontes, Danilo Augusto Ferreira¹ 

关键词: UV-Vis spectroscopy;    Efavirenz;    analytical method.;   

DOI  :  10.1590/S0100-40422010000900026

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

An UV-Vis spectrophotometry analytical method for quantifying Efavirenz was developed and validated as an alternative to replace the HPLC current method. The report method presents sample concentration of 10 μg mL-1, dissolved in a solution ethanol:water (60:40, v/v), economic and technically adequate for the purpose adopted. The results and the statistical treated proved that the method being considered an precise and accurate analytical low cost alternative for laboratory routine. The adaptability of this method in product and other analytical methods development has been challenged by mathematical calculation of drug extinction coefficient in water and methanol and practical experiments, showing interesting results.

【 授权许可】

Unknown