Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures

Química Nova

Daniel R. Delgado¹  Miller A. Ruidiaz¹  Sandra M. Gómez¹  Mauricio Gantiva¹  Fleming Martínez¹ 

[1] ,Universidad Nacional de Colombia Departamento de Farmacia Bogotá D.C. ,Colombia

关键词: cosolvency;    sodium naproxen;    solubility;   

DOI  :  10.1590/S0100-40422010000900019

来源: SciELO

【 摘 要 】

By using the van't Hoff and Gibbs equations the apparent thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for sodium naproxen in ethanol + water cosolvent mixtures, were evaluated from solubility data determined at temperatures from (278.15 to 308.15) K. The drug solubility was greatest in neat water and lowest in neat ethanol at all the temperatures studied. By means of non-linear enthalpy-entropy compensation analysis, it follows that the dissolution process of this drug in ethanol-rich mixtures is entropy-driven, whereas, in water-rich mixtures the process is enthalpy-driven.

【 授权许可】

CC BY-NC   
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