Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures

Quimica nova

Gómez, Sandra M.¹  Delgado, Daniel R.¹  Ruidiaz, Miller A.¹  Gantiva, Mauricio¹  Martínez, Fleming¹ 

[1] Universidad Nacional de Colombia, Bogotá, Colombia

关键词: cosolvency;    sodium naproxen;    solubility.;   

DOI  :  10.1590/S0100-40422010000900019

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

By using the van'tHoff and Gibbs equations the apparent thermodynamic functions Gibbs energy,enthalpy, and entropy of solution for sodium naproxen in ethanol + water cosolventmixtures, were evaluated from solubility data determined at temperatures from(278.15 to 308.15) K. The drug solubility was greatest in neat water and lowestin neat ethanol at all the temperatures studied. By means of non-linear enthalpy-entropycompensation analysis, it follows that the dissolution process of this drugin ethanol-rich mixtures is entropy-driven, whereas, in water-rich mixturesthe process is enthalpy-driven.

【 授权许可】

CC BY