Estabilização do ácido lipoico via encapsulação em nanocápsulas poliméricas planejadas para aplicação cutânea

Química Nova

Irene Clemes Külkamp²  Karina Paese¹  Sílvia Stanisçuaski Guterres¹  Adriana Raffin Pohlmann¹ 

[1] ,Universidade Federal do Rio Grande do Sul Faculdade de Farmácia

关键词: nanocapsules;    lipoic acid;    stabilization;   

DOI  :  10.1590/S0100-40422009000800018

来源: SciELO

【 摘 要 】

This work reports the development of polymeric nanocapsules containing lipoic acid prepared by interfacial deposition of poli(ε-caprolactona). The suspensions showed acid pH and encapsulation efficiencies from 77 to 90%. Zeta potential values were from -7.42 to -5.43 mV and particle sizes were lower than 340 nm with polidispersion lower than 0.3. The stability of nanocapsules within 28 days was evaluated in terms of pH, lipoic acid content, diameter, size distribution, zeta potential and measurements of relative light backscattering. The stability of formulations containing free lipoic acid was also evaluated. Nanoencapsulation drastically improved the physico-chemical stability of lipoic acid.

【 授权许可】

CC BY-NC   
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