Stabilization of lipoic acid by encapsulation in polymeric nanocapsules designed for cutaneous administration

Quimica nova

Külkamp, Irene Clemes¹  Pohlmann, Adriana Raffin²  Guterres, Sílvia Stanisçuaski³  Paese, Karina³ 

[1] Universidade Federal do Rio Grande do Sul;Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil;Universidade do Sul de Santa Catarina, Tubarão, Brasil

关键词: nanocapsules;    lipoic acid;    stabilization.;   

DOI  :  10.1590/S0100-40422009000800018

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work reports the development of polymeric nanocapsules containing lipoic acid prepared by interfacial deposition of poli(ε-caprolactona). The suspensions showed acid pH and encapsulation efficiencies from 77 to 90%. Zeta potential values were from -7.42 to -5.43 mV and particle sizes were lower than 340 nm with polidispersion lower than 0.3. The stability of nanocapsules within 28 days was evaluated in terms of pH, lipoic acid content, diameter, size distribution, zeta potential and measurements of relative light backscattering. The stability of formulations containing free lipoic acid was also evaluated. Nanoencapsulation drastically improved the physico-chemical stability of lipoic acid.

【 授权许可】

CC BY